منابع مشابه
Calpain regulates neutrophil chemotaxis.
Cell polarization is required for directed cell migration. We investigated the role of the calcium-dependent protease calpain during neutrophil chemotaxis and found that calpain inhibition induced neutrophil adhesion, polarization, and rapid chemokinesis in the absence of exogenous activators. Resting neutrophils display constitutive calpain activity with mu-calpain being the predominant active...
متن کاملAdenosine promotes neutrophil chemotaxis
We have previously (1-4) demonstrated that adenosine, by engaging specific receptors on the surface of neutrophils, inhibits generation of toxic oxygen metabolites by activated neutrophils and prevents these activated neutrophils from injuring endothelial cells. We now report the surprising observation that engagement of these same neutrophil adenosine receptors promotes chemotaxis to C5 fragme...
متن کاملNeutrophil chemotaxis and anaesthesia.
Using a modified Boyden technique, the ability of normal human neutrophils to migrate in response to chemotactic stimulation was evaluated during exposure in vitro to halothane and thiopentone. No abnormality in neutrophil chemotaxis could be demonstrated with either agent at concentrations used clinically. The anaesthetics also did not effect serum complement, which was used as the chemotactic...
متن کاملCirculating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis.
Thioredoxin (Trx), a redox enzyme with a conserved active site (Cys-32-Gly-Pro-Cys-35), is induced and secreted into circulation in response to inflammation. Studies here demonstrate that elevating Trx levels in circulation either by i.v. injection of recombinant Trx or stimulating Trx release in Trx-transgenic mice dramatically blocks lipopolysaccharide (LPS)-stimulated neutrophil migration in...
متن کاملChicken soup inhibits neutrophil chemotaxis in vitro.
Chicken soup has long been regarded as a remedy for symptomatic upper respiratory tract infections. As it is likely that the clinical similarity of the diverse infectious processes that can result in "colds" is due to a shared inflammatory response, an effect of chicken soup in mitigating inflammation could account for its attested benefits. To evaluate this, a traditional chicken soup was test...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Cell
سال: 2010
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2010.11.017